Cisplatin transporter

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August undefined, 2024

WebJan 17, 2024 · System x c − is one among many amino acid transporters expressed in the plasma membrane of mammalian cells 1.This transporter is composed of xCT (SLC7A11), which is the substrate-specific ... Webwww.ncbi.nlm.nih.gov

Cisplatin - Wikipedia

WebApr 30, 2015 · Cisplatin is one of the first-line platinum-based chemotherapeutic agents for treatment of many types of cancer, including ovary cancer. CTR1 (copper transporter 1), a transmembrane solute carrier transporter, has previously been shown to increase the cellular uptake and sensitivity of cisplatin. It is hypothesized that increased CTR1 … WebIn addition, cisplatin is the standard treatment of patients with non-small cell lung cancer (NSCLC) when druggable mutations are not present in the tumour 34. Hence, Pt drugs have not been... phosphorescing

The copper transporter ctr1 and cisplatin accumulation at the …

WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … WebMay 11, 2012 · Cisplatin is a prescription medicine used alone to treat bladder and ovarian cancer.It is also used together with other drugs to help treat testicular cancer, locally … WebEffects of siRNA-GLUT-1 and LY294002 on apoptosis and cell cycle in Hep-2 cells after treatment with cisplatinBefore the cisplatin treatment, the apoptotic rates of cells in the siRNA-GLUT-1 and LY294002 groups were increased markedly at 24 hours and 48 hours compared with the Hep-2 cell and siRNA-NC groups (P<0.05; Figure 2).The early … phosphoresis

Current Strategies to Combat Cisplatin-Induced …

Significance of downregulation of renal organic cation transporter ...

WebOct 7, 2002 · Cisplatin is a chemotherapeutic drug used to treat a variety of cancers. Both intrinsic and acquired resistance to cisplatin, as well as toxicity, limit its effectiveness. … WebCisplatin is mainly internalised by the copper transporter CTR1. Accordingly, CTR1 down-regulation has been associated with resistance to platinum-based drugs in cancer [ 10 , 11 ]. Cellular inactivation of cisplatin and subsequent sequestration can be mediated by binding to cytoplasmic nucleophilic factors, including glutathione (GSH) and ... how does acid reflux cause nauseaWebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the … how does acid reflux affect the throat

"WebApr 24, 2015 · Cisplatin seems to interact preferentially with hOCT2 (Ciarimboli et al., 2005), suggesting that hOCT2 is the critical transporter for renal cisplatin uptake in … " - Cisplatin transporter

Cisplatin transporter

Significance of downregulation of renal organic cation transporter ...

WebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the activation of intrinsic resistance mechanisms in cancer cells. Among them, we can find mutations, … WebApr 14, 2024 · HIGHLIGHTS. who: ICP-TOF et al. from the Autonomous University of Madrid, Spain have published the research: The copper transporter CTR1 and cisplatin accumulation at the single-cell level by LA-ICP-TOFMS, in the Journal: (JOURNAL) what: In this study, total CTR1 levels (comprising plasma_membrane-associated and intracellular …

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WebFeb 23, 2007 · Ctr1, the major copper influx transporter, has been convincingly demonstrated to transport cisplatin and its analogues, carboplatin, and oxaliplatin. … WebApr 26, 2024 · Full article: Update on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advanced in vitro testing Expert Opinion on Drug Metabolism & Toxicology Volume 17, 2024 - Issue 6 Open access 2,926 Views 2 CrossRef citations to date 0 Altmetric Listen Review

WebFeb 23, 2007 · Ctr1, the major copper influx transporter, has been convincingly demonstrated to transport cisplatin and its analogues, carboplatin, and oxaliplatin. Evidence also suggests that the two copper efflux transporters ATP7A and … WebDec 14, 2024 · Cisplatin (CDDP) is a chemotherapy drug commonly used in systemic treatment of germ cell tumors, including cancers of the ovaries, testes, and solid tumors of the head and neck 1.

WebMay 17, 2024 · They postulated that cisplatin could compete with copper for CTR1-mediated transport, but did not further investigate the consequences on copper homeostasis or potential modification of CTR1. Platinum coordination may also alter conformation or block necessary amino acids for native Cu (I) interactions. WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in …

WebAug 1, 2016 · Cisplatin Pazopanib Renal transporters OCT-2 Drug-drug interaction 1. Introduction Angiogenesis inhibitors represent a promising approach in the treatment of …

WebSep 18, 2024 · NCBI Bookshelf phosphorescent powder woodWebCisplatin triggers rapid degradation of Copper Transporter 1, reducing influx of cisplatin and increasing resistance to it. Explore the transporter in PDB ID 6m97 . Glutathione transferase (GST) P1-1 is a cisplatin-binding protein that can inactivate cisplatin. how does ackermans give back to the communityWebHydroxytyrosol protects against cisplatin-induced nephrotoxicity via attenuating CKLF1 mediated inflammation, and inhibiting oxidative stress and apoptosis. ... of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κ B pathway and regulating transporter mediated drug efflux. Journal of Ethnopharmacology, 2024 ... how does acirt workWebApr 14, 2024 · Flavonoids are enriched in various vegetables, fruits, and herbal products, and some were reported to produce transporter-mediated DDIs. This study aimed to screen potential inhibitors of OCT2 from 96 flavonoids, assess the nephroprotective effects on cisplatin-induced kidney injury, and clarify the structure-activity relationships of ... how does acidity affect enzymesWebFeb 28, 2024 · However, the principal mechanisms by which 13 and, above all, 18 overcome cisplatin resistance rely on three different possible mechanisms: the inhibition of endogenous P-gp expression, a transporter that enables the active efflux of the drug from the cancer cells; the generation of ROS inside the cells that can reduce GSH levels, a … how does acidosis lead to deathWebNov 15, 2024 · Magnesium co-administration decreases cisplatin-induced nephrotoxicity in the multiple cisplatin administration Life Sci. 2024 Nov 15;189:18-22. doi: 10.1016/j ... Expression of renal organic cation transporter 2 (rOct2) and multidrug and toxin extrusion protein 1 (rMate1), which are involved in CDDP transport, did not differ between the … phosphoretedWebJul 22, 2009 · Organic cation transporter 2 (OCT2) has been implicated in the cellular uptake of cisplatin, but its role in cisplatin-induced nephrotoxicity remains unknown. In mice, deletion of Oct1 and Oct2 resulted in significantly impaired urinary excretion of cisplatin without an apparent influence on plasma levels. phosphoresistant