Biologically relevant motifs

Author: jbfs

August undefined, 2024

WebMay 11, 2004 · Whether we can define modules in a stringent biologically relevant fashion is not just important for our understanding of the organization of biological systems. Many authors have conjectured that if modules are real they may also be more likely to contain proteins that are essential to viability. ... In the case of the 5' motifs, the statistic ... WebSep 10, 2014 · Biologically relevant linear motifs often exhibit a statistical significance that lies in or near the twilight zone (i.e. where there is a non-negligible probability to observe a random motif) . This difficulty begs for a better understanding and characterization of motif statistical significance [2] , [18] , and calls for alternative approaches.

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WebApr 21, 2024 · The fact that these motifs represent many of the known functional components of gammaproteobacterial oriC sequences further supports the finding that … WebJul 1, 2024 · Studies demonstrating their existence in the human genome and role in gene regulation are now shining light on their biological relevance. Herein, we review the … churches hannibal mo

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WebMay 14, 2024 · Here we present a novel approach to identify such motifs in protein three-dimensional structures without depending on sequence alignment by representing … WebJul 1, 2024 · The unique structure and biological roles of i-motifs make them attractive potential targets for small molecule binding to modulate transcriptional activity. ... In turn this will give rise to further research into aberrant modifications and subsequent impact on these biologically relevant structures within abnormal cell types. While there is ... WebMar 1, 2024 · Thus, such biologically relevant portions of chemical space may only be accessible by exploiting features encoded and subsequently passed-on through the incorporation of structural motifs generated by secondary metabolite biosynthesising proteins, which themselves share evolutionary conserved structural features. 13 This … developed countries and climate change

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WebJan 11, 2024 · We show that LncLOOM is capable of identifying specific, biologically relevant motifs which are conserved throughout vertebrates and beyond in lncRNAs … WebAn important aspect is that under normal cellular concentrations, biologically relevant motifs will generally outcompete lower affinity off-target instances 38 (the implications for motif definitions based purely on … churches hanover paWebJan 13, 2024 · Overall, these findings suggest that shortening the upstream region increases the signal-to-noise ratio to detect biologically relevant motifs and, at the same time, reduces the occurrence of low complexity AT-rich motifs. In Figure 3, we illustrate a clear example of this observation. Indeed, with both oligo and dyad analysis, the statistical ... churches hardware ashburton

"WebFeb 7, 2008 · We conclude that many biologically relevant motifs appear heterogeneously distributed in the promoter region of genes, and therefore, that non-uniformity is a good indicator of biological relevance and can be used to complement over-representation tests commonly used. In this article we present the results obtained for the S. cerevisiae data … " - Biologically relevant motifs

Biologically relevant motifs

Stability and context of intercalated motifs (i-motifs) for biological ...

WebMay 14, 2024 · Identification of biologically relevant motifs in proteins is a long-standing problem in bioinformatics, especially when considering distantly related proteins where … WebJun 1, 2024 · The ability of this method to rapidly synthesize various types of biologically relevant 1,3-dienyl-6-oxy motifs is highlighted in Figs. 6c and 7. The direct applicability of this method was ...

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Web2 days ago · Network maps for endophenotypes in the human interactome are enriched with disease genes, further supporting the idea that disease genes form biologically relevant clusters in the broader network ...

WebDownload Table Detailed Overview of Selected Biologically Relevant Motifs from publication: A Novel Algorithm for Enhanced Structural Motif Matching in Proteins As widely discussed in ... WebMay 20, 2024 · Herein, we highlight examples of biologically relevant tertiary structures that have been successfully targeted and the strategies that yielded these promising …

WebJan 11, 2024 · We show that LncLOOM is capable of identifying specific, biologically relevant motifs which are conserved throughout vertebrates and beyond in lncRNAs … WebJul 7, 2009 · A unique motif GX{P}[LMQ]X{P}XX{P}X{CIMPVW} was identified as a sufficient condition for peptide binding to Ydj1p. Yeast proteome screen revealed that the motif is biologically relevant and could be observed in many proteins involved in cochaperone activity, with Ydj1p and others involved in critical cellular events.

WebJul 7, 2009 · A unique motif GX{P}[LMQ]X{P}XX{P}X{CIMPVW} was identified as a sufficient condition for peptide binding to Ydj1p. Yeast proteome screen revealed that the …

WebMay 14, 2024 · Identiﬁcation of biologically relevant motifs in proteins is a long-standing problem in bioinformatics, especially when considering distantly related proteins where … churches hardware wilkesboroWebOct 18, 2024 · Below the two exons, the motifs are represented by the PDB structures of 3MJH and 1WJ0, mapped using HHPRED. ... However, some alternative protein isoforms are also biologically relevant 34,35 ... developed countries gdp per capitaWebMar 16, 2024 · Fig. 5: Scope of diarylation of biologically relevant motif coupled alkynes and synthetic applications. All reactions are carried out on a 0.2 mmol scale. All the compounds are isolated as a ... developed countries have a high level ofWebDec 23, 2024 · Jun Yang, Federico Ariel, Dong Wang, Plant long non-coding RNAs: biologically relevant and mechanistically intriguing, Journal of Experimental Botany, Volume 74, Issue 7, 9 April 2024, ... (IPS1), had a 23-nt motif complementary to miR399 and functioned as the target mimic of miR399, sequestering miRNA399 away from its … developed countries farming technologyWebBiological motion is motion that comes from actions of a biological organism. Humans and animals are able to understand those actions through experience, identification, and … churches hanover park ilWebMar 11, 2010 · The approach successfully discovers biologically relevant motifs and their intervals of localization in scenarios where the motifs cannot be discovered by general motif finding tools. It is especially useful for discovering multiple co-localized motifs in a set of regulatory sequences, such as those identified by ChIP-Seq. developed countries in south americaWebMay 16, 2024 · Identification of biologically relevant motifs from MetaChrom. To better understand what have been learned by our model, we extracted representative sequence patterns from our model using TF-MoDISco and TOMTOM (See Method 4.9). To focus on cell-type specific sequence features, we first sampled DNA sequence bins from our test … developed countries of the world